Bring a large pot of salted water to a boil. Cook the macaroni one to two minutes less than what the package directions dictate. Drain and reserve.
Melt butter in a skillet. Add garlic and cook for 30 seconds, stirring constantly. Whisk in the flour.
Whisk in the heavy cream and milk and stir in seasonings. Bring to a simmer. Stir in the cheeses until they melt.
Once the cheese melts and turns into a creamy sauce, add the cooked macaroni and stir well to coat the pasta.
Spoon half the pasta into the baking dish and top with shredded cheese. Repeat with the other half of pasta and sprinkle panko on top of the cheese. Place in the smoker and smoke for an hour.